Products
DAMYARANARAK
Closantel bolus (as Na) 500 mg
For veterinary use only.
Category: Anthelmintic (Salicylanilides).
Form: Oral bolus
Compound: Each bolus contains 500 mg Closantel (as Na).
Target Animal: Cattle, calf, sheep and goat.
Indication:
Closantel bolus is used to prevent and treat of immature form of Trematodes, Nematodes and larval stages of some Arthropods.
• Cattle, calf, sheep and goat:
1- Trematodes: Mature and immature Fasciola hepatica and Fasciola gigantica between 6 weeks of age or higher.
2- Nematodes: Chabertia ovina, Oesophagostomum, Haemonchus and Bunostomum.
3- Arthropods’ larvae: Oestrus ovis, Hypoderma bovis and Hypoderma lineatum.
Mode of Action: By controlling succinate dehydrogenase enzymes and fumarate reductase, Closantel bolus disrupts oxidative phosphorylation of parasitized cells’ mitochondria, preventing ATP production. Also it disrupts ions and fluid transfer mechanisms within parasitized cells’ membrane.
Pharmacokinetic: Once administered orally, Closantel quickly gets absorbed within blood circulation and its plasmatic concentration reaches maximum level in 24- 28 hours. The Closantel’s unchanged molecule fully (99% <) bonds with plasma albumin, hence, limiting its distribution within tissues. Its half-life in plasma is 3-4 weeks. A small quantity is metabolized and its excretion mostly takes place via bile and a small portion of it via urine.
Dosage and Administration:
Cattle and calf:
• 5 mg/ kg Closantel bolus (Half a bolus per 50 kg bodyweight): To treat Fasciola hepatica and gigantica, Haemonchus, Bunostomum and Oesophagostomum.
• 10 mg/ Closantel bolus (1 bolus per 50 kg bodyweight): To treat Hypoderma bovis and Hypoderma lineatum.
Sheep and goat:
• 5 mg/ kg Closantel bolus (Half a bolus per 50 kg bodyweight): To treat Haemonchus, Oesophagostomum, Oestrus ovis.
• 10 mg/ kg Closantel bolus (1 bolus per 50 kg bodyweight): To treat Fascioloides magna and Lucilia cuprina.
Cautions: Keep out of reach of children and avoid drug’s direct contact with eyes and mucosal membranes. Wash your hands once you administer the drug.
Contraindication: Closantel bolus to be prescribed for dairy animals during their ablactation period. The milk of animals in which Closantel is used should not be consumed by humans.
Drug Interaction: None.
Withdrawal Time: 28 days for meat.
Side Effects: Studies have shown that drug’s treatable dose is well tolerated among cattle and sheep and does not have any side effects. The immunity level for cattle is 6 times and for sheep 4 times the treatable consuming quantity.
Preservation: Keep in a dry place, away from direct light and at room temperature (Below 30°C).
Packing: Boxes of 100 boluses (10X 10 blisters)/ Polyethylene containers of 100 and 200.