Products
DAMYARANARAK
Doxycycline (Hyclate) solution 10%
For veterinary use only.
Category: Antibiotic (Tetracyclines).
Form: Oral solution.
Compound: Each ml of solution contains 100 mg Doxycycline (Hyclate).
Target Animal: Poultry.
Indication: Doxycycline is effective upon prevention and treatment of digestive and respiratory systems’ infections resulted by microorganism sensitive to Doxycycline such as Bordetella, Campylobacter, E coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus, Streptococcus subspecies, Chlamydia and Rickettsia. Also, it’s twice as effective against gram-positive and gram-negative bacteria, compared to other Tetracyclines and it’s the best tetracycline against gram-positive bacteria.
Mode of Action: Doxycycline is broad spectrum bacteriostatic anti-biotic which prevents protein synthesis in bacteria, once it connects to 30S ribosomal subunit.
Pharmacokinetics: Once administered orally, Doxycycline quickly gets absorbed via intestine. Food’s presence in intestine doesn’t affect drug’s absorption. This medicine influences and distributes well throughout body tissues. Once absorbed, it metabolizes a little and in contrary to other Tetracyclines, its excretion takes place via feces. Therefore, it can be used in case of renal failure.
Poultry: 6 hours after oral administration, it reaches a stable plasma concentration and varies between 1.28 – 2.18 µg/ml.
Dosage and Administration:
Poultry: To be prescribed in 50 -100 mg per L (Equivalent to 0.5 to 1 ml in 1 L) drinking water for 3-5 days.
Drinking water which contains the drug must be consumed by 12 hours.
Cautions: Keep out of reach of children.
Drug interaction: Not to be used along with anti-acids that contain divalent Cations or Trivalent Cations (Aluminum, Calcium, Magnesium, Zinc and Bismuth ions) which decrease Doxycycline absorption. Not to be used concurrently with Penicillins, Cephalosporins, and Aminoglycosides. Phenobarbitals might decrease Doxycycline’s half-life.
Contraindication: Not to be used in layer poultry in which their egg will be used by human.
Withdrawal Time:
Poultry: 5 days.
Preservation: Store in a dry place, at room temperature (below 30ºC) and away from light.
Packing: 120, 250, 500 and 1000 ml polyethylene bottles.