Damyantel®

Closantel Sodium Dihydrate 5% 
For veterinary use only
Category: Anthelmintic (Salicylanilides).
Form: Oral suspension.
Compound: Each ml of oral suspension contains 50 mg Closantel (as Sodium dihydrate salt).
Target Animal: Sheep, goat, cattle and calf.
Indication: Closantel is used to control and treat parasitic infestations caused by Trematodes like Fasciola hepatica and Fasciola gigantica and or parasitic infestations caused by Nematodes such as Haemonchus contortus, Haemonchus placei, Bunostomum and Oesophagostomum species. Also, this medicine is effective upon few parasitic arthropods’ larva such as Hypoderma bovis, Hypoderma lineatum, Oestrus ovis and Lucilia cuprina.
Mode of action: By influencing Mitochondrial membrane, Closantel prevents oxidative phosphorylation and electron’s transfer, hence, blocking ATP formation and eventually killing parasite due to drastic change in its metabolism.
Pharmacokinetics: Once administered orally, Closantel quickly gets absorbed by blood circulation and reaches maximum plasmatic concentration in 24-48 hours after oral administration. The unchanged Closantel molecule completely (99% <) bonds with Plasma Albumin making its distribution among tissues very rare. Its half-life in plasma is 3-4 weeks. A very small quantity is metabolized and its excretion via gallbladder and a little portion of it via urine.
 
Dosage and Administration: Once the bottle is shaken well, administer the suspension orally via drenching gun:
Sheep and goat:

1. 10 mg per kg bodyweight (1 ml suspension per 5 kg bodyweight) in order to eliminate Fasciola hepatica, Fasciola gigantica, Gaigeria pachyscelis, Chabertia ovina and Oesophagostomum columbianum.
2. 5 mg per kg bodyweight (1 ml per 10 kg bodyweight) in order to eliminate Haemonchus contortus and Oestrus ovis.
3. 15 mg per kg bodyweight (1 ml per 3.3 kg bodyweight) in order to eliminate Fascioloides magna and Lucilia cuprina.

Cattle and calf:

1. 5 mg per kg bodyweight (3 ml per 30 kg bodyweight) in order to eliminate Fasciola hepatica and gigantica, Haemonchus placei, Bunostomum phlebotomum and Oesophagostomum radiatum.
2. 10 mg per kg bodyweight (3 ml per 15 kg bodyweight) in order to eliminate Hypoderma bovis and Hypoderma lineatum.

• Due to Closantel’s expected half-life, animals that undergo treatment won’t be re-infected with nematodes for few weeks.

Contraindication: Not to be used concurrently with compounds containing Chlorine (like insecticides) in order to prevent poisonous reactions.
Side Effects: None if the drug is prescribed according to the advisable dosage and it can be used for young, pregnant and disabled animals. Closantel is well tolerated in animals’ body and its immunity level is 6 times (Cattle) and 4 times (Sheep) the treatable consuming quantity.
Cautions: Keep out of reach of children. Shake the bottle well before consumption. Must be consumed under vet’s direct supervision. Avoid drug’s direct contact with eyes and mucus. Once the drug is administered, wash your hands.
 
Withdrawal Time: 

• Meat: 28 days
• Milk: 28 days

It’s advised that Closantel be prescribed during cattle and sheep’s dry period (ablactation).
Preservation: Keep in room temperature (below 30ºC) and away from direct light. Be protected from freezing.
Packing: Polyethylene bottles of 120, 250, 500 and 1000 ml.