Products
DAMYARANARAK
Levamisole Hydrochloride solution 7.5%
For veterinary use only.
Category: Anthelmintic (Imidazothiazoles).
Form: Oral solution.
Compound: Each ml of solution contains 75 mg Levamisole Hydrochloride.
Target Animal: Cattle, sheep and goat.
Indication: Damyazole OS ® solution is an effective anthelmintic consumed for control and treatment of nematodes in larval and adult stages in gastrointestinal and respiratory system such as Haemonchus spp, Ostertagia spp, Trichostrongylus spp and Cooperia spp in cattle, sheep and goat. Levamisole also has a significant effect upon lung’s Dictyocaulus spp.
Mode of Action: By directly influencing worms’ neural system, Levamisole quickly paralyzes them, facilitating their easy detachment from respiratory mucus, digestive tube and their rapid exit from animal’s body. Hence, with minimal damage to mucus and animal’s digestive system, entire respiratory and digestive worms present in body will be eliminated and excreted.
Pharmacokinetic:
Once administered orally, Levamisole quickly gets absorbed and its plasmatic concentration reaches maximum level in 3 hours. Once the absorption process is complete, Levamisole distributes vastly and promptly throughout different tissues. Levamisole is mainly metabolized in liver and less than 5% of it remains unchanged which will be excreted via urine. 90% of the entire prescribed dose will be excreted in 24 hours. Metabolites mainly are excreted via urine and a little via feces.
Dosage and Administration:
Cattle, sheep and goat:
7.5 mg per kg bodyweight (1 ml per 10 kg livestock weight) administered to animal via drencher or a needleless syringe. In order to attain the right dosage of this drug you need to calculate the precise weight of animal as well as the efficiency of drencher device.
– For cattle with more than 300 kg bodyweight, for every 10 kg administer 1 ml extra.
– For sheep with more than 60 kg bodyweight, for every 5 kg administer 0.5 ml extra.
In cases of pregnant ewes, it is advised that Levamisole HCL solution be administered once, six weeks prior to parturition and the second time after weaning process is over.
Caution:
Due to its close therapeutic and toxic dose, it is advised not to consume quantity more than prescribed by vet.
Drug Interaction:
This drug interacts with Chloramphenicol, Pyrantel and Organophosphorus compounds and it is essential that there will be a 14-day gap time between consumption of Levamisole HCL solution and rest of these drugs.
Withdrawal Time:
4 days for milk, 21 days for sheep and goat’s meat, 14 days for cattle’s meat.
Preservation: Be kept in sealed containers, away from light, at room temperature (below 30°C) and out of reach of children. Once the container is open, its component must be consumed by 30 days.
Packing: 120, 500 and 1000 ml polyethylene bottles.