Neomycin 20% Solution

Neomycin 20% Solution
For veterinary use only.
Category: Antibiotic (Aminoglycosides).
Form: Oral solution.
Compound: Each ml of solution contains 200 mg Neomycin sulfate.
Target Animal: Cattle, calf, sheep, goat and poultry.
Indication: Neomycin is effective on aerobic gram negative bacteria such as Escherichia coli, Salmonella, Proteus, Klebsiella and some aerobic gram positive bacteria. This medicine is prescribed to treat enteritis as well as poultry and livestock’s diarrhea caused by aerobic gram-negative bacteria.
Mode of Action: Neomycin has a bactericidal effect on aerobic gram-negative bacteria when it has an irreversible connection with 30S ribosomal subunit; hence, preventing protein synthesis in bacteria cell.
Pharmacokinetics: Approximately 3% of Neomycin prescribed dose which has been administered orally will systematically be absorbed and the rest will be excreted through feces without any change (˃90%). The absorbed Neomycin will be excreted by kidney through glomerular filtration process.
Dosage and Administration:
 Poultry

• 1 L in 4000 L of drinking water beginning from day 1 up to two weeks of age for 3-5 days.
• 1 L in 3000 L of drinking water beginning from week 3 up to week 5 for 3-5 days.
• 1 L in 2000-2500 L of drinking water beginning from week 6 up to the end of growth period for 3-5 days.

Turkey

• 1 L in 2500 L of drinking water beginning from day 1 to day 7^th of age for 3-5 days.
• 1 L in 1500 L of drinking water beginning from week 2 up to the end of week 8 for 3-5 days.
• 1 L in 1200 L of drinking water beginning from week 9 up to 26^th weeks of age for 3-5 days.

Calf, sheep and goat

• 11 ml of solution per 100 kg body weight (22 mg Neomycin sulfate per kg body weight) in drinking water for 3-5 days.

Drug Interaction: Not to be used concurrently with nephrotoxic medicines, ionophore compounds such as Salinomycin, Monensin and Narasin and 1 week before or after the prescription of Tiamulin.
Contraindication: Not to be used in cases of hypersensitivity to aminoglycosides, renal failure or intestinal obstruction. This medicine is prohibited for newborn animals and old animals due to toxicity enhancement. Not to be prescribed for milking cows during their lactating period.
Side Effects: Oral consumption of Neomycin rarely disrupts hearing, nephrotoxic effects, acute diarrhea and impaired absorption of material from gastrointestinal wall.
Cautions: Not to be consumed for more than 5 consecutive days. Prepared solution containing this medicine must be consumed by maximum 12 hours. Keep out of reach of children.
Withdrawal Time: 

• Poultry: 7 days.
• Turkey: 14 days.
• Calf: 30 days.
• Sheep and goat: 20 days.
• Egg: 14 days.
• Milk: 2 days.

Preservation: Kept in a dry place, away from direct light and at room temperature (below 30ºC). Be protected from freezing.
Packing: Polyethylene bottles of 120, 250, 500 and 1000 ml.